This study analyzes the current performance and forecasts future demand for the strategic Eastern Mediterranean ports of Iskenderun, Botaþ, and Mersin, which are vital for Türkiye’s international trade and energy logistics. The research aims to identify economic drivers influencing port performance and guide infrastructure and investment strategies. With rising competition between Mersin and Iskenderun, the study evaluates how these ports can meet future cargo demands and what growth strategies are appropriate. Data were collected from port authorities and national sources, including GDP, population, exports, and imports. Key performance indicators such as gross tonnage, stevedoring activity, container capacity, and vessel numbers were assessed. Using multiple linear regression, the study projected port performance over ten years with a 2% annual growth in economic indicators. Results show that in Iskenderun, population growth has a strong positive effect on gross tonnage (coefficient = 5.79, p < 0.01, R² = 0.99), emphasizing its cost-efficient logistics. Mersin demonstrates notable container capacity growth (R² = 0.95), also driven by population growth. In contrast, Botaþ shows weaker correlations (R² < 0.51), likely due to operational limits. The study recommends improving hinterland infrastructure in Iskenderun and expanding capacity in Mersin. Future studies should further investigate Botaþ’s constraints.